칼슘과 비타민D 섭취가 티타늄 임플랜트 주위의 골 형성에 미치는 영향
On bone formation around titanium implant
박광일, 이재열, 황대석, 김용덕, 김규천, 신상훈, 김욱규, 정인교,
소속 상세정보
박광일 ( Park Kwang-Il ) - 부산대학교 치과대학 구강악안면외과학교실
이재열 ( Lee Jae-Yeol ) - 부산대학교 치과대학 구강악안면외과학교실
황대석 ( Hwang Dae-Seok ) - 부산대학교 치과대학 구강안면외과학교실
김용덕 ( Kim Yong-Deok ) - 부산대학교 치과대학 구강안면외과학교실
김규천 ( Kim Gyoo-Cheon ) - 부산대학교 치과대학 구강해부학교실 및 구강생물공학연구소
신상훈 ( Shin Sang-Hun ) - 부산대학교 치과대학 구강안면외과학교실
김욱규 ( Kim Uk-Kyu ) - 부산대학교 치과대학 구강안면외과학교실
정인교 ( Jung In-Kyo ) - 부산대학교 치과대학 구강안면외과학교실
KMID : 0355620070330020131
Abstract
The purpose of this study was to observe the effect of calcium and vitamin D to the titanium implant osseointegration in animal model. 32 rats, 10 weeks of age, were divided into two group: additional calcium and vitamin D supplementation group and a control group. Titanium screw implant(diameter, 2.0mm; length, 3.5mm; pitch-height 0.4 ㎜) were placed into tibia of 32 rats, 16 in the control group and 16 in the experimental group. The rats were sacrificed at different time interval(1, 2, 4, and 8 weeks after implantation) for histopathologic observation, histomorphometric analysis and immunohistochemistry with osteocalcin and osteopontin antibody. Histopathologically findings, newly formed bone was seen at 1 weeks and became lamellar bone at 2 weeks, and mature trabecullar bone was seen at 4 weeks experimental group. In control group, thickness of regenerated bone increased till 4 weeks gradually and trabecullar bone was seen at 8 weeks. By histomorphometric analysis, bone marrow density was increased significantly at 1 and 2 weeks in experimental group compared to control group. Osteocalcin immunoreactivity was strong at 1 week experimental group and reduced after 4 weeks gradually. But it was continuously weakly from 1 to 4 weeks in control group. Osteopontin immunoreactivity was very strong in newly formed bone from 2 to 8 weeks experimental group. And the amount of osteopontin expression was more abundant in experimental group. The results of this study suggest that calcium and vitamin D supplementation promotes bone healing around dental implants
키워드
Calcium;Vitamin D;Implant
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